SECOND GENERATION VISCOSUPPLEMENT
INDICATED IN THE TREATMENT OF KNEE OSTEOARTHRITIS
HYALURONIC ACID + MANNITOL
MEDICAL DEVICE – 3 x 2 ml pre-filled syringes
High Molecular Weight
HAppyVisc™ is a visco-elastic gel which combines high molecular weight hyaluronic acid of 1.5 million Daltons and mannitol.
High concentration for prolonged activity
HAppyVisc™ contains high concentration of hyaluronic acid (1.55%) i.e. 31 mg/syringe. HAppyVisc™ brings 50% more hyaluronic acid than a traditional visco-elastic solution.
Mannitol
HAppyVisc™ contains high concentration of mannitol (70 mg/syringe).
Long-lasting effect: Mannitol is an anti-oxidant which protects hyaluronic acid chains from free radicals and limits their degradation increasing then their residence time in the joint cavity.
Analgesic effect: Due to its free radical scavenging properties, mannitol also ensures local analgesic effect.
Stabilizer: Because it is a thermal stabilizer, mannitol allows HAppyVisc™ to guarantee a stability of its rheological properties all along its storage.
Safe
HAppyVisc™ is highly purified and results from bacterial fermentation.
Experimental/Clinical studies
- Randomized, prospective, multicenter, parallel group study comparing the efficacy and safety of HAPPYVISC® vs. EUFLEXXA® in the treatment of symptomatic knee osteoarthritis. X. Chevalier; V. Legre; T. Conrozier (ongoing)
- Role of high concentrations of mannitol on the stability of hyaluronan in an oxidative stress model induced by xanthine/xanthine oxidase. M.Rinaudo, B.Lardy, Th.Conrozier (results available, c.f. poster presentation)
