Addition of Mannitol to Hyaluronic Acid may Shorten Viscosupplementation Onset of Action in Patients with Knee Osteoarthritis: Post-Hoc Analysis of A Double-blind, Controlled Trial. Eymard F, Bossert M, Lecurieux R, Maillet B, Chevalier X, et al. (2016) J Clin Exp Orthop 2: 21. doi: 10.4172/2471-8416.100021

OBJECTIVE: To compare the speed of action of three weekly intra-articular injections of a combination of hyaluronic acid and mannitol (HAnox-M) with that of hyaluronic acid alone (BioHA), in patients with knee osteoarthritis (OA).

RESULTS: Our results suggest that mannitol might have beneficial effect on HA performances, by reducing pain more rapidly than HA alone, especially in patients with severe knee OA. The mechanisms by which mannitol could shorten the onset of action of viscosupplementation remain to be investigated.

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