SECOND GENERATION VISCOSUPPLEMENT 

INDICATED IN THE TREATMENT OF ANKLE, HIP, SHOULDER and KNEE OSTEOARTHRITIS

UNIQUE COMBINATION OF CROSS-LINKED HYALURONIC ACID + MANNITOL

HAppyCross

MEDICAL DEVICE – 1 x 2.2 ml pre-filled syringe (SINGLE INTRA-ARTICULAR INJECTION)

 

High concentration for prolonged activity

HAppyCross™ contains high concentration of hyaluronic acid (1.6%) i.e. 35.2 mg/syringe.

 

IPN technoCross-linked Hyaluronic Acid

HAppyCross™ is a cross-linked hyaluronic acid gel (IPN-Like technology). Cross-linking:

  • Ensures a gel-like rheological behaviour, maximizing then the mechanical properties of hyaluronic acid.
  • Increases the residence time of the gel in the joint cavity, preventing biodegradation from free radicals and enzymes.

IPN-Like Technology: a unique and patented cross-linking process

Compared to the classic cross-linking technique, the IPN-Like technology, or InterPenetrated Cross-linked Networks, involves combining, inserting one into another, two monophasic hyaluronic acid networks previously purified and cross-linked which are mechanically independent.  Interpenetration of Cross-linked Networks:

  • Optimizes the density of the chemical bonds while minimizing the use of reticulating agent (BDDE) within the monophasic gel, ensuring a longer-lasting effect of the product.
  • Preserves the partial independence of the inter-penetrated networks and guarantees the gel is supple and easy to inject into the joint.

Mannitol

HAppyCross™ also contains high concentration of mannitol (77mg/syringe).

Long-lasting effect: Mannitol is an anti-oxidant which protects hyaluronic acid chains from free radicals and limits their degradation, increasing then their residence time in the joint cavity.

Analgesic effect: Due to its free radical scavenging properties, mannitol also ensures local analgesic effect.

Stabilizer: because it is a thermal stabilizer, mannitol allows HAppyCross™ to guarantee a stability of its rheological properties all along its storage.

Safe

HAppyCross™ is highly purified and results from bacterial fermentation.

Experimental/Clinical Studies

HAPPYCROSS IN THE HIP
HAPPYCROSS IN THE ANKLE
HAPPYCROSS IN THE KNEE
  • Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial. Henrotin Y., Berenbaum F., Chevalier X., Marty M., Richette P., Rannou F. BMC Musculoskelet Disord. 2017 May 26;18(1):222. doi: 10.1186/s12891-017-1585-2. -Publication-

This study has been conducted with biomarkers in order to demonstrate that HAppyCross reduces cartilage degradation in patients with knee OA (decrease of the biomarkers of type II collagen). This study shows HAppyCross is effective to decrease degradation of collagen but has not been designed to show any clinical effects.

OTHER STUDIES
  • Decision Algorithms for the Retreatment with Viscosupplementation in Patients Suffering from Knee Osteoarthritis. Recommendations from the EUROpean VIScosupplementation COnsensus Group (EUROVISCO). R. Raman, Y. Henrotin, X. Chevalier, A. Migliore, J. Jerosch, J. Montfort, H. Bard, D. Baron, P. Richette, T. Conrozier. Cartilage. February-01-2017. Doi: 10.1177/1947603517693043 -Publication-