Safety and efficacy of intra-articular injections of a combination of hyaluronic acid and mannitol (HAnOX-M) in patients with symptomatic knee osteoarthritis. Results of a double-blind, controlled, multicenter, randomized trial. T. Conrozier, F. Eymard, N. Afif, JC. Balblanc, V. Legré-Boyer, X. Chevalier, on behalf of the Happyvisc Study. The Knee. 2016. Read more…
Steroids, lidocaine and ioxaglic acid modify the viscosity of hyaluronic acid: in vitro study and clinical implications. T. Conrozier; J. Patarin; P. Mathieu; M. Rinaudo. SpringerPlus . 2016 Feb 24;5:170; doi: 10.1186/s40064-016-1762-z. During viscosupplementation, it is usual to inject other drugs, without knowing whether this association may have a deleterious Read more…
TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells by C. Baugé et al. BMC Complementary and Alternative Medicine 2015; 15:217; doi 10.1186/s12906-015-0748-7. Abstract Background Tendinopathies are tendon conditions associated with degeneration and disorganization of the matrix collagen fibers, tendon cells apoptosis and inflammation through up-regulation of Read more…
Viscosupplementation with HANOX-M-XL (HAppyCross®) is effective in moderate hip osteoarthritis but is not an alternative to hip joint surgery in patients with severe disease. Results of a “real life” clinical survey in 191 patients. T.Conrozier; M. Bossert; A. Walliser-Lohse; M. Sondag; JC Balblanc. Eur J Musculoskeletal Dis. 2015; 2:49-55. The Read more…
Mannitol Preserves the Viscoelastic Properties of Hyaluronic Acid in an In Vitro Model of Oxidative Stress by Thierry Conrozier, Pierre Mathieu, Marguerite Rinaudo, Rheumatology and Therapy, December 2014, Volume 1, Issue 1, pp 45-54; doi:10.1007/s40744-014-0001-8. – published online 25 July 2014. Abstract: Introduction Viscosupplementation by intra-articular injection of hyaluronic acid Read more…