SECOND GENERATION VISCOSUPPLEMENT

INDICATED IN THE TREATMENT OF KNEE OSTEOARTHRITIS

HYALURONIC ACID + MANNITOL

 

MEDICAL DEVICE – 3 x 2 ml pre-filled syringes

High Molecular Weight

HAppyVisc™ is a visco-elastic gel which combines high molecular weight hyaluronic acid of 1.5 million Daltons and mannitol.

High concentration for prolonged activity

HAppyVisc™ contains high concentration of hyaluronic acid (1.55%) i.e. 31 mg/syringe. HAppyVisc™ brings 50% more hyaluronic acid than a traditional visco-elastic solution.

Mannitol

HAppyVisc™ contains high concentration of mannitol (70 mg/syringe).

Long-lasting effect: Mannitol is an anti-oxidant which protects hyaluronic acid chains from free radicals and limits their degradation increasing then their residence time in the joint cavity.

Analgesic effect: Due to its free radical scavenging properties, mannitol also ensures local analgesic effect.

Stabilizer: Because it is a thermal stabilizer, mannitol allows HAppyVisc™ to guarantee a stability of its rheological properties all along its storage.

Safe

HAppyVisc™ is highly purified and results from bacterial fermentation.

Experimental/Clinical studies

  • Impact of Obesity, Structural Severity and Their Combination on the Efficacy of Viscosupplementation in Patients With Knee Osteoarthritis. T. Conrozier, F. Eymard, M; Chouk, X. Chevalier. BMC Musculoskelet Disord 2019 Aug 17;20(1):376. doi: 10.1186/s12891-019-2748-0-Publication-

    • Obesity and Radiological Severity Are Associated With Viscosupplementation Failure in Patients With Knee OsteoarthritisEymard F, Chevalier X, Conrozier T. J Orthop Res. 2017 Oct;35(10):2269-2274. doi: 10.1002/jor.23529-Publication-

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