Impact of the Addition of Ginger Extract and Copper Sulphate to Glucosamine Sulphate on Il-1β- Stimulated Chondrocytes. Rousset F, Grange L, Nguyen MVU, Pinosa-Zezza C, Gaudin P, et al. J Rheum Dis Treat 2016 2:038

Osteoarthritis (OA) is a common disorder characterized by loss of articular cartilage as a result of degenerative changes in the joint. Interleukin-1β (IL-1β) is the main cytokine involved in OA progression leading to an increase in MMP release by chondrocytes and a decrease in synthesis of extracellular matrix component such as proteoglycans or type II collagen. In response to IL-1β, chondrocytes actively produce reactive oxygen species (ROS) which could play a central role in this matrix homeostasis breakdown.

In order to optimize the Glucosamine sulphate (Gs) efficacy against osteoarthritis, a new therapeutic association (Glucosamine Copper Ginger)(GsCG) has been developed  [Cuivramine®, Laboratoire Labhra, Lyon, France].

OBJECTIVE: The aim of the study was to compare in vitro the potential additional effects of the association of Glucosamine-Copper-Ginger (GsCG) versus Glucosamine (Gs) alone on the level of ROS production, the MMP expression and chondrocyte apoptosis upon IL-1β stimulation.


Effects of Cuivramine on IL-1B

This study provided experimental evidence that glucosamine sulfate decreases ADAMTS5 expression and apoptosis. In addition, ginger root and copper sulphate decreased pro-MMP1 expression by regulating NOX4 activity. Our data suggest the implication of Heme Oxygenase-1 in the molecular mechanisms.

In conclusion, GsCG (Cuivramine®) displays supplementary beneficial effects compared to Gs alone and addition of Copper sulphate and Ginger root extract could improve Gs therapeutic efficiency in patients with OA.

Cu: Copper Sulphate; GsCG: Glucosamine-Copper-Ginger; GR: Ginger Root Extract; Gs: Glucosamine Sulphate; HO-1: Heme Oxygenase-1; IL: Interleukin; MMP: Matrix Metalloproteases; Nox: NADPH Oxidase; OA: Osteoarthritis; ROS: Reactive Oxygen Species

Results of this study have been presented in a poster displayed at the OARSI Congress in Barcelona in 2012 as well as at the SFR Congress in Paris the same year.

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