Safety and efficacy of single intra-articular injection of a mannitol-modified cross-linked Hyaluronic acid (Happycross) in knee osteoarthritis.

Safety and efficacy of single intra-articular injection of a mannitol-modified cross-linked Hyaluronic acid (Happycross) in knee osteoarthritis.

Abstract Objectives: To assess, in daily practice conditions, both safety and efficacy of a single intra-articular injection of a cross-linked hyaluronic acid (HA) combined with mannitol (HANOX-M-XL) in patients with symptomatic knee osteoarthritis. Methods: We analyzed the clinical and radiological Read more…

Study on viscosupplementation

The Association between Radiographic Features and the Duration of Effectiveness of a Single Injection of Extended-Release Hyaluronic Acid (HANOX-M-XL) in Patients with Knee Osteoarthritis.

  Preliminary Results of a Prospective Trial. Solène Perruchet, Jean-Charles Balblanc, Charles Rapp, Charlotte Bourgoin, Cerise Guillochon, Anne Lohse, Thierry Conrozier.   Background. Advanced radiological stage of knee osteoarthritis (OA) is predictive of poor response to viscosupplementation (VS). To date, Read more…