SECOND GENERATION VISCO-ELASTIC SOLUTION

INDICATED IN THE TREATMENT OF PAIN IN SMALL JOINTS AFFECTED BY OSTEOARTHRITIS

UNIQUE COMBINATION OF CROSS-LINKED HYALURONIC ACID + MANNITOL

 

 

Image HAppyMini

 

MEDICAL DEVICE – 1 x 1 ml (SINGLE INTRA-ARTICULAR INJECTION)

Appropriate Volume

HAppyMini® is supplied in a 1ml pre-filled syringe and is entirely appropriate for intra-articular injection into:

TMC joint of the thumb   -   Fingers   -   Big toe   -   Temporomandibular joint   -   Wrist   -   Subtalar joint

High Concentration for Prolonged Activity

HAppyMini® contains high concentration of hyaluronic acid: 1.6% i.e. 16 mg/syringe.

 

IPN technoCross-Linked Hyaluronic Acid

HAppyMini® is a cross-linked hyaluronic acid gel (IPN-Like technology)
Cross-linking:

  • Ensures a gel-like rheological behaviour, maximizing then the mechanical properties of hyaluronic acid.
  • Increases the residence time of the gel in the joint cavity, preventing biodegradation from free radicals and enzymes.

IPN-Like Technology: a unique and patented cross-linking process

Compared to the classic cross-linking technique, the IPN-Like technology, or InterPenetrated Cross-linked Networks, involves combining, inserting one into another, two monophasic hyaluronic acid networks previously purified and cross-linked which are mechanically independent.  Interpenetration of Cross-linked Networks:

  • Optimizes the density of the chemical bonds while minimizing the use of reticulating agent (BDDE) within the monophasic gel, ensuring a longer-lasting effect of the product.
  • Preserves the partial independence of the inter-penetrated networks and guarantees the gel is supple and easy to inject into the joint.

Mannitol

HAppyMini® also contains high concentration of mannitol (35mg/syringe).

Long-lasting effect: Mannitol is an anti-oxidant which protects hyaluronic acid chains from free radicals and limits their degradation, increasing then their residence time in the joint cavity.

Analgesic effect: Due to its free radical scavenging properties, mannitol also ensures local analgesic effect.

Stabilizer: because it is a thermal stabilizer, mannitol allows HAppyCross™ to guarantee a stability of its rheological properties all along its storage.

Safe

HAppyMini® is highly purified and results from bacterial fermentation.

Experimental/Clinical Studies

HAPPYMINI IN THE TEMPOROMANDIBULAR JOINT
  • Treatment of Temporomandibular joint OA with an intra-articular injection of Hyaluronic acid: Predictive factors of patient’s satisfaction 6 months after a single intra-articular injection of HAppyMini. Study conducted on around 50 patients -Ongoing- 
HAPPYMINI IN THE TRAPEZIOMETACARPAL JOINT
  • Influence of the radiological grade on the efficacy of an intra-articular injection of hyaluronic acid (HAppyMini) in patients with Trapeziometacarpal osteoarthritis. Study conducted on 122 patients. -Ongoing-

The preliminary results on the first 64 patients have been presented in a poster at the OARSI Congress in Las Vegas in April 2017 as well at the ISIAT Congress in October 2017 in Prague.

HAPPYMINI IN THE BIG TOE
  • Is the radiological grade a predictive factor of efficacy of an intra-articular injection of hyaluronic acid (HAppyMini) in patients suffering from Hallux rigidus?Prospective survey on around 60 patients treated in private medical care -Ongoing-
OTHER STUDIES
  • Decision Algorithms for the Retreatment with Viscosupplementation in Patients Suffering from Knee Osteoarthritis. Recommendations from the EUROpean VIScosupplementation COnsensus Group (EUROVISCO). R. Raman, Y. Henrotin, X. Chevalier, A. Migliore, J. Jerosch, J. Montfort, H. Bard, D. Baron, P. Richette, T. Conrozier. Cartilage. February-01-2017. Doi: 10.1177/1947603517693043 -Publication-