CUIVRAMINE®: Beneficial effects of the therapeutic association of Glucosamine, Copper and Ginger demonstrated. Read our paper

Published by admin on



Impact of the Addition of Ginger Extract and Copper Sulphate to Glucosamine Sulphate on Il-1β- Stimulated Chondrocytes. Rousset F, Grange L, Nguyen MVU, Pinosa-Zezza C, Gaudin P, et al. J Rheum Dis Treat 2016 2:038

Osteoarthritis (OA) is a common disorder characterized by loss of articular cartilage as a result of degenerative changes in the joint. Interleukin-1β (IL-1β) is the main cytokine involved in OA progression leading to an increase in MMP release by chondrocytes and a decrease in synthesis of extracellular matrix component such as proteoglycans or type II collagen. In response to IL-1β, chondrocytes actively produce reactive oxygen species (ROS) which could play a central role in this matrix homeostasis breakdown.

In order to optimize the Glucosamine sulphate (Gs) efficacy against osteoarthritis, a new therapeutic association (Glucosamine Copper Ginger)(GsCG) has been developed  [Cuivramine®, Laboratoire Labhra, Lyon, France].

OBJECTIVE: The aim of the study was to compare in vitro the potential additional effects of the association of Glucosamine-Copper-Ginger (GsCG) versus Glucosamine (Gs) alone on the level of ROS production, the MMP expression and chondrocyte apoptosis upon IL-1β stimulation.


Effects of Cuivramine on IL-1B

This study provided experimental evidence that glucosamine sulfate decreases ADAMTS5 expression and apoptosis. In addition, ginger root and copper sulphate decreased pro-MMP1 expression by regulating NOX4 activity. Our data suggest the implication of Heme Oxygenase-1 in the molecular mechanisms.

In conclusion, GsCG (Cuivramine®) displays supplementary beneficial effects compared to Gs alone and addition of Copper sulphate and Ginger root extract could improve Gs therapeutic efficiency in patients with OA.

Cu: Copper Sulphate; GsCG: Glucosamine-Copper-Ginger; GR: Ginger Root Extract; Gs: Glucosamine Sulphate; HO-1: Heme Oxygenase-1; IL: Interleukin; MMP: Matrix Metalloproteases; Nox: NADPH Oxidase; OA: Osteoarthritis; ROS: Reactive Oxygen Species

Results of this study have been presented in a poster displayed at the OARSI Congress in Barcelona in 2012 as well as at the SFR Congress in Paris the same year.

Read Full Text