Experimental studies and clinical trials are endlessly conducted on our products. All experimental studies and clinical trials to date have shown significant results. Several of them have been published in international peer-reviewed scientific journals. LABRHA also displays each year several scientific posters at different congresses.

Viscosupplements:

HAPPYVISC

 

 

 

  • Impact of Obesity, Structural Severity and Their Combination on the Efficacy of Viscosupplementation in Patients With Knee Osteoarthritis. T. Conrozier, F. Eymard, M; Chouk, X. Chevalier. BMC Musculoskelet Disord 2019 Aug 17;20(1):376. doi: 10.1186/s12891-019-2748-0-Publication-

 

HAPPYCROSS IN THE HIP

 

 

  • Hip Inflammation MRI Scoring System (HIMRISS) to Predict Response to Hyaluronic Acid Injection in Hip Osteoarthritis. Deseyne N, Conrozier T, Lellouche H et al. Joint Bone Spine. 2018 Jul;85(4):475-480. doi: 10.1016/j.jbspin.2017.08.004.-Publication-

 

HAPPYCROSS IN THE ANKLE

A cohort study on 50 patients treated with HAppyCross® for ankle osteoarthritis has been presented as a poster at the French Society of Rheumatology Congress in 2014. A paper related to this study has been written and is currently in press. Preliminary results on the first 20 patients included have been presented in a poster displayed at the International Symposium Intra-Articular Treatment (ISIAT), Barcelona, on the 3-5 October 2013.

 

HAPPYCROSS IN THE KNEE

 

 

 

  • Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial. Henrotin Y., Berenbaum F., Chevalier X., Marty M., Richette P., Rannou F. BMC Musculoskelet Disord. 2017 May 26;18(1):222. doi: 10.1186/s12891-017-1585-2. -Publication-

This study has been conducted with biomarkers in order to demonstrate that HAppyCross reduces cartilage degradation in patients with knee OA (decrease of the biomarkers of type II collagen). This study shows HAppyCross is effective to decrease degradation of collagen but has not been designed to show any clinical effects.

 

MANNITOL 

 

 

 

 

HAPPYMINI IN THE TEMPOROMANDIBULAR JOINT

 

HAPPYMINI IN THE TRAPEZIOMETACARPAL JOINT

  • Safety and Predictive Factors of Short-Term Efficacy of a Single Injection of Mannitol-Modified Cross-Linked Hyaluronic Acid in Patients With Trapeziometacarpal Osteoarthritis. Results of a Multicentre Prospective Open-Label Pilot Study (INSTINCT Trial) Dauvissat J, Rizzo C, Lellouche H et al. Clin Med Insights Arthritis Musculoskelet Disord. 2018 Jun 21;11:1179544118782901. doi: 10.1177/1179544118782901-Publication- 

 

HAPPYMINI IN THE BIG TOE

 

HAPPYMINI IN THE PATELLO-FEMORAL CHONDROPATHY

 

 USE OF VISCOSUPPLEMENTATION IN THE MANAGEMENT OF OA

 

LABRHA is the organizer of the “European Board on Viscosupplementation” which takes place every year in Lyon. This event get together the best European experts in viscosupplementation to allow them to debate during 2 days on a specific topic related to viscosupplementation and work together towards the common goal of publishing papers in renowned international scientific journals. Publications are available on the website of the group EUROVISCO : eurovisco.com

 

    Food supplements:

    FIBROMYALGINE

     

    CICATENDON 

    • In vitro study evaluating the effect of a dietary supplement combining different antioxidants (Cicatendon®) in a human model of tendinopathy. C. Baugé C; K. Boumediene; S. Leclercq;  T. Conrozier. Oral Communication at the 25th congress of the French Society of Rheumatology (SFR). Rev Rhum 2012; 79 (Suppl. 1).

     

    CUIVRAMINE 

    Results of this study have been presented in a poster displayed at the OARSI Congress in Barcelona in 2012 as well as at the SFR Congress in Paris the same year.

     

    AINAT 

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